- Review Article
- Oncology
- Prognostic factors and treatment of pediatric acute lymphoblastic leukemia
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Jae Wook Lee, Bin Cho
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Clin Exp Pediatr. 2017;60(5):129-137. Published online May 31, 2017
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The event-free survival (EFS) for pediatric acute lymphoblastic leukemia (ALL) has shown remarkable improvement in the past several decades. In Korea also, a recent study showed 10-year EFS of 78.5%. Much of the improved outcome for pediatric ALL stems from the accurate identification of prognostic factors, the designation of risk group based on these factors, and treatment of appropriate duration... |
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- Original Article
- Cardiology
- Subclinical left ventricular dysfunction in children after hematopoietic stem cell transplantation for severe aplastic anemia: a case control study using speckle tracking echocardiography
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Beom Joon Kim, Kyung Pil Moon, Ji-Hong Yoon, Eun-Jung Lee, Jae Young Lee, Seong Koo Kim, Jae Wook Lee, Nack Gyun Chung, Bin Cho, Hack Ki Kim
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Clin Exp Pediatr. 2016;59(4):190-195. Published online April 30, 2016
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Purpose Severe aplastic anemia (SAA), a fatal disease, requires multiple transfusion, immunosuppressive therapy, and finally, hematopoietic stem cell transplantation (HSCT) as the definitive treatment. We hypothesized that iron overloading associated with multiple transfusions and HSCTrelated complications may adversely affect cardiac function. Left ventricular (LV) function was assessed in children after HSCT for SAA. MethodsForty-six consecutive patients with a median age of 9.8... |
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- Case Report
- Use of intravenous immunoglobulin in a disseminated varicella infection in an immunocompromised child
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Jae Hong Kim, Dae Hyun Kwon, E Young Bae, Seung Beom Han, Jae Wook Lee, Nack Gyun Chung, Dae Chul Jeong, Bin Cho, Jin Han Kang, Hack Ki Kim
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Clin Exp Pediatr. 2014;57(8):370-373. Published online August 25, 2014
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Varicella-zoster virus infection can lead to severe illness in immunocompromised patients. Further the mortality rate of disseminated varicella infection is extremely high particularly in immunocompromised children. We report a case of disseminated varicella infection in a child with acute lymphoblastic leukemia who was receiving chemotherapy, but was initially admitted with only for acute abdominal pain. The patient rapidly developed severe... |
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- Review Article
- BK virus-associated hemorrhagic cystitis after pediatric stem cell transplantation
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Seung Beom Han, Bin Cho, Jin Han Kang
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Clin Exp Pediatr. 2014;57(12):514-519. Published online December 31, 2014
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Hemorrhagic cystitis is a common stem cell transplantation-related complication. The incidence of early-onset hemorrhagic cystitis, which is related to the pretransplant conditioning regimen, has decreased with the concomitant use of mesna and hyperhydration. However, late-onset hemorrhagic cystitis, which is usually caused by the BK virus, continues to develop. Although the BK virus is the most common pathogenic microorganism of poststem... |
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- Original Article
- Efficacy of imatinib mesylate-based front-line therapy in pediatric chronic myelogenous leukemia
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Hyun Jin Oh, Mun Sung Cho, Jae Wook Lee, Pil-Sang Jang, Nack-Gyun Chung, Bin Cho, Hack-Ki Kim
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Clin Exp Pediatr. 2013;56(8):343-350. Published online August 27, 2013
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Purpose Despite the established role of imatinib (IM) in chronic myelogenous leukemia (CML) in adults, there are few reports on its efficacy in children. In this study, we compared the outcomes of children with CML before and after the advent of IM-based treatment. MethodsThe study cohort consisted of 52 patients treated for CML at the Department of Pediatrics, The Catholic University of... |
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- Risk factors for short term thyroid dysfunction after hematopoietic stem cell transplantation in children
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You Jin Jung, Yeon Jin Jeon, Won Kyoung Cho, Jae Wook Lee, Nack-Gyun Chung, Min Ho Jung, Bin Cho, Byung-Kyu Suh
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Clin Exp Pediatr. 2013;56(7):298-303. Published online July 19, 2013
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Purpose The purpose of this study was to evaluate short-term thyroid dysfunction and related risk factors in pediatric patients who underwent hematopoietic stem cell transplantation (HSCT) during childhood. MethodsWe studied 166 patients (100 boys and 66 girls) who underwent HSCT at the Catholic HSCT Center from January 2004 through December 2009. The mean age at HSCT was 10.0±4.8 years. Thyroid function of... |
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- Utility of a multiplex reverse transcriptase-polymerase chain reaction assay (HemaVision) in the evaluation of genetic abnormalities in Korean children with acute leukemia: a single institution study
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Hye-Jin Kim, Hyun Jin Oh, Jae Wook Lee, Pil-Sang Jang, Nack-Gyun Chung, Myungshin Kim, Jihyang Lim, Bin Cho, Hack-Ki Kim
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Clin Exp Pediatr. 2013;56(6):247-253. Published online June 21, 2013
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Purpose In children with acute leukemia, bone marrow genetic abnormalities (GA) have prognostic significance, and may be the basis for minimal residual disease monitoring. Since April 2007, we have used a multiplex reverse transcriptase-polymerase chain reaction tool (HemaVision) to detect of GA. MethodsIn this study, we reviewed the results of HemaVision screening in 270 children with acute leukemia, newly diagnosed at The... |
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- Immune reconstitution after allogeneic hematopoietic stem cell transplantation in children: a single institution study of 59 patients
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Hyun O Kim, Hyun Jin Oh, Jae Wook Lee, Pil-Sang Jang, Nack-Gyun Chung, Bin Cho, Hack-Ki Kim
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Clin Exp Pediatr. 2013;56(1):26-31. Published online January 29, 2013
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Purpose Lymphocyte subset recovery is an important factor that determines the success of hematopoietic stem cell transplantation (HSCT). Temporal differences in the recovery of lymphocyte subsets and the factors influencing this recovery are important variables that affect a patient's post-transplant immune reconstitution, and therefore require investigation. MethodsThe time taken to achieve lymphocyte subset recovery and the factors influencing this recovery were investigated... |
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- Evaluation of changes in random blood glucose and body mass index during and after completion of chemotherapy in children with acute lymphoblastic leukemia
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Kyong-Won Bang, Soo Young Seo, Jae Wook Lee, Pil-Sang Jang, Min Ho Jung, Nack-Gyun Chung, Bin Cho, Dae-Chul Jeong, Byung Kyu Suh, Hack-Ki Kim
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Clin Exp Pediatr. 2012;55(4):121-127. Published online April 30, 2012
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Purpose Improved survival of patients with childhood acute lymphoblastic leukemia (ALL) has drawn attention to the potential for late consequences of previous treatments among survivors, including metabolic syndrome. In this study, we evaluated changes in 3 parameters, namely, random blood glucose, body mass index (BMI), and Z score for BMI (Z-BMI), in children with ALL during chemotherapy and after completion of... |
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- Outcome of allogeneic hematopoietic stem cell transplantation for childhood acute lymphoblastic leukemia in second complete remission: a single institution study
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Eun-Jung Lee, Ji Yoon Han, Jae Wook Lee, Pil-Sang Jang, Nack-Gyun Chung, Dae-Chul Jeong, Bin Cho, Hack-Ki Kim
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Clin Exp Pediatr. 2012;55(3):100-106. Published online March 16, 2012
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Purpose The survival rate for childhood acute lymphoblastic leukemia (ALL) has improved significantly. However, overall prognosis for the 20 to 25% of patients who relapse is poor, and allogeneic hematopoietic stem cell transplantation (HSCT) offers the best chance for cure. In this study, we identified significant prognostic variables by analyzing the outcomes of allogeneic HSCT in ALL patients in second complete... |
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- Distribution of CD4+CD25+ T cells and graft-versus-host disease in human hematopoietic stem cell transplantation
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Dae Hyoung Lee, Nak Gyun Chung, Dae Chul Jeong, Bin Cho, Hack Ki Kim
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Clin Exp Pediatr. 2008;51(12):1336-1341. Published online December 15, 2008
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Purpose : This study aimed to determine the frequencies of CD4+CD25+ T cells in donor graft and peripheral blood CD4+CD25+ T cells in recipients after hematopoietic stem cell transplantation (HSCT) and their association with graft-versus-host disease (GVHD).
Methods : Seventeen children who underwent HSCT were investigated. CD4+CD25+ T cells in samples from donor grafts and recipient peripheral blood were assessed... |
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- Clinical outcomes of hematopoietic stem cell transplantation from
HLA-matched parental donor in childhood acute leukemia
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Eun Young Cha, Moon Hee Lee, Jae Wook Lee, Young Joo Kwon, Dae Hyoung Lee, Young-Shil Park, Nak Gyun Chung, Dae Chul Jeong, Bin Cho, Hack Ki Kim
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Clin Exp Pediatr. 2008;51(1):67-72. Published online January 15, 2008
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Purpose : In this study, we retrospectively analyzed the clinical outcomes of patients who underwent allogeneic hematopoietic stem cell transplantation (HSCT) grafted from HLA-matched parents.
Methods : Seven children with acute leukemia (4 acute lymphoblastic leukemia, 3 acute myeloid leukemia) in first complete remission received allogeneic HSCT from their respective parents at the St. Marys Hospital between April, 1999 and October,... |
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- The effects of shortened dexamethasone administration on
remission rate and potential complications during remission
induction treatment for pediatric acute lymphoblastic leukemia
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Jae Wook Lee, Kwang Hee Lee, Young Joo Kwon, Dae Hyoung Lee, Nak Gyun Chung, Dae Chul Jeong, Bin Cho, Hack Ki Kim
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Clin Exp Pediatr. 2007;50(12):1217-1224. Published online December 15, 2007
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Purpose : Due to its high potency against leukemic blasts, our institution has opted for the use of dexamethasone during acute lymphoblastic leukemia (ALL) remission induction, but in our most recent treatment protocol, CMCPL-2005, we shortened the length of steroid treatment from 4 to 3 weeks. We compared both the rates of remission induction and significant complications observed during induction... |
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- CMV antigenemia following pediatric hematopoietic stem cell transplantation : risk factors and outcomes
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Eun-Young Cho, Young-Shil Park, Dae-Hyung Lee, Ji Kyoung Park, Sangrhim Choi, Sun Young Kim, Pil-Sang Jang, Dong-Gun Lee, Nak-Gyun Chung, Jong Hyun Kim, Dae-Chul Jeong, Bin Cho, Jae Gyun Hur, Jin Han Kang, Hack-Ki Kim
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Clin Exp Pediatr. 2006;49(2):173-180. Published online February 15, 2006
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Purpose : Cytomegalovirus(CMV) infection still remains as a major cause of morbidity and mortality after stem cell transplantation. In this study, we analyzed the results of antigenemia-guided pre- emptive therapy among children with allogeneic hematopoietic stem cell transplantation to determine the incidence and risk factors associated with CMV antigenemia, and evaluated the efficacy of the CMV antigenemia based preemptive therapy.... |
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- Short-term follow up of thyroid function after pediatric hematopoietic stem cell transplantation
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Seon-Ju Lee, Jae-Wook Lee, Dae-Hyoung Lee, Young-Joo Kwon, Young-Shil Park, Hui Sung Hwang, Sun Young Kim, Ji Kyoung Park, Pil-Sang Jang, Min-Ho Jung, Nak-Gyun Chung, Dae-Chul Jeong, Bin Cho, Hack-Ki Kim, Byung-Churl Lee
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Clin Exp Pediatr. 2006;49(11):1211-1215. Published online November 15, 2006
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Purpose : In this study, we analyzed the short term changes of thyroid function, incidence and risk factors of thyroid dysfunction soon after allogeneic hematopoietic stem cell transplantation (HSCT) in children.
Methods : We enrolled 80 pediatric patients following allogeneic HSCT, at the Catholic HSCT center between January, 2004 and February, 2006. Serum TSH (thyroid stimulating hormone), total serum thyroxine and... |
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- Case Report
- A Case of G-6-PD Guadalajara
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Gi Bum Lee, Sun Ju Lee, Yoo Jung Kim, So Young Kim, Hyun Hee Kim, Bin Cho, Wonbae Lee
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Clin Exp Pediatr. 2004;47(2):210-213. Published online February 15, 2004
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Glucose-6-phosphate dehydrogenase(G-6-PD) deficiency is a disease that shows hemolytic anemia and jaundice caused by injury of erythrocytes. The gene of G-6-PD has 13 exons and locates in Xq28, and over 150 mutations of this gene have been reported. We experienced a G-6-PD deficienct male patient who was suffering hemolytic anemia and jaundice confirmed by measuring low G-6-PD activity in the... |
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- Original Article
- Short-term Results of Hematopoietic Stem Cell Transplantation
for Children with Myelodysplastic Syndrome
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Jin Lee, Soh Yeon Kim, Bin Cho, Pil Sang Jang, Nak Gyun Chung, Hack Ki Kim
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Clin Exp Pediatr. 2002;45(3):370-375. Published online March 15, 2002
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Purpose : In most cases, myelodysplastic syndrome(MDS) transforms into a more aggressive state or acute myelogenous leukemia; it's prognosis is very poor. It is believed that hematopoietic stem cell transplantation(HSCT) is the only curative treatment of MDS, but available data in children are very sparse. In this report, the short term outcome of HSCT in childhood MDS was analyzed.
Methods :... |
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- Change of Peripheral Blood CD5+ B Lymphocytes in Early Neonatal Period
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Ye Ho Lee, Bin Cho, Department of Pediatrics, College of Medicine, Cat , Kyung Tai Whang
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Clin Exp Pediatr. 2000;43(5):674-678. Published online May 15, 2000
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Purpose : This study was aimed to investigate age-related changes of CD5+ B lymphocytes in healthy Korean neonates.
Methods : Sixty healthy neonatal infants were enrolled in this study; at birth(n=10), day 1(n=10), day 2(n=10), day 3(n=10), day 4(n=10) and day 5(n=10). Phenotypic analysis of CD5+ B lymphocytes was performed on blood samples using standard flow-cytometric techniques.
Results : The percentage of... |
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- One Hundred Cases of HLA-matched Sibling Allogeneic bone Marrow Transplantation in Children : Single Center Study
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Hack Ki Kim, Bin Cho, Nak Gyun Chung, Dae Chul Jeong, Soh Yeon Kim, Hyun Jung Lee, Kyong Su Lee, Kyung Ja Han, Won Il Kim, Il Bong Choi, Chun Choo Kim
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Clin Exp Pediatr. 2000;43(3):402-410. Published online March 15, 2000
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Purpose : We reviewed 100 cases of HLA-matched sibling allogeneic bone marrow transplantation(
allo-BMT) in children and wish to share these results.
Methods : One hundred children had undergone allo-BMT from HLA-identical siblings between Nov.
1983 and May 1998. There were 50 males and 50 females with a median age of 10 years and a
median follow-up of 38 months. Out of 100 cases,... |
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- Case Report
- A Case of von Gierke Disease
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Young A Joe, Moon Young Song, Bin Cho, Soon Ju Lee, In Kyung Sung, Kyong Su Lee
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Clin Exp Pediatr. 1997;40(12):1756-1760. Published online December 15, 1997
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von Gierke disease(type Ia glycogen storage disease) is an inherited disease associated
with accumulation of glycogen in the liver, kidney, intestine and erythrocytes due to the
defect of glucose-6-phosphatase activity.
Hepatomegaly, doll face, anemia, bleeding tendency and increased susceptability to infection
are common features observed during infancy. Hypoglycemia especially fasting
hypoglycemia is typical metabolic derangement in this disease, followed by metabolic
acidosis, lactic acidemia, hyperlipidemia, hyperuricemia,... |
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- Original Article
- Immunologic Abnormalitiesin Kawasaki Diseaseand the Effect
ofIntravenousImmunoglobulin
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Joon Sung Lee, Bin Cho, Sung Hoon Cho
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Clin Exp Pediatr. 1996;39(5):691-702. Published online May 15, 1996
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Purpose : It has been suggested that immunologic abnormalities play a role in the
pathogenesis of vascular injury in Kawasaki disease and the immunologic abnormalities
could be regulated by high-dose intravenous immunoglobulin(IVIG). We investigated
the peripheral blood lymphocyte subsets, the serum levels of interleukin-6(IL-6) and
tumor necrosis factor-α(TNF-α) and the effect of high-dose IVIG(400 mg/kg/day for
5 days) on these factors during acute stage of... |
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- Clinical Study of Graves` Diseasein Children : Remission and Relaps
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Moon Young Song, Bin Cho, Byung Churl Lee
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Clin Exp Pediatr. 1996;39(3):389-396. Published online March 15, 1996
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Purpose : This study was carried out to evaluate the age and sex distribution, clinical manifestation, presence of the antithyroid antibody, the clinical outcome following antithyroid drug treatment in children with Graves' disease.
Methods : A total 45 children with Graves' disease were entered into the study. Diagnosis was based on clinical manifestation, elevated thyroid function and increased homogeneous 99mTc thyroid... |
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- Cough Variant Asthma
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Bin Cho, Joon Sung Lee
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Clin Exp Pediatr. 1995;38(10):1340-1348. Published online October 15, 1995
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Purpose : Asthma, one of the most common of chronic cough in children, is easily diagnosed when classic triad; cough, wheezing, dyspnea are presented. However, it has become apparant that cough may be the sole manifestation of this disease. This cough variant asthma is underdiagnosed and undertreated. The clinical manifestations and subject variables of asthma especially, cough variant asthma had... |
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- Chronic Cough in Children
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Bin Cho, Joon Sung Lee, Kyung Tai Whang, Sung Hoon Cho
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Clin Exp Pediatr. 1994;37(8):1116-1123. Published online August 15, 1994
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Chromic cough is a symptom frequently encountered by the pediatrician. Although most coughs are self-limited, chronic cough ofter proves to be a frustrating problem.
This study was performed at Kangnam St. Mary's Hospital from January 1,1992 to December 31, 1992, and 83 children with chronic cough persisting for longer than 3 weeks was evaluated.
We categorized these patients into 5... |
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- Case Report
- A Case of Idiopathic Hypereosinophilic Syndrome
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Bin Cho, Jin Tack Kim, Joon Sung Lee, Kyoo Hong Cho
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Clin Exp Pediatr. 1994;37(7):1020-1027. Published online July 15, 1994
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The idiopathic hypereosinophilic syndrome(HES) represents a heterogenous group of disorder characterized by prolonged eosinophilia of undetectable cause and multiorgan system dysfunction.
Bone marrow is the most frequentry involved organ, but the most severe clinicopathologic involvement is heart. The major cause of death in patients with the HES is cardiac dysfunction especially congestive heart failure resulted from endocardial fibrosis and restrictive cardiomyopathy.
We... |
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- A Case of Distal Renal Tubular Acidosis
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Bin Cho, Dong Sung Kim, Byung Churl Lee
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Clin Exp Pediatr. 1994;37(1):115-112. Published online January 15, 1994
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Distal renal tubular acidosis (RTA) is a biochemical syndrome as a dificiency of hydrogen ion secretion by the distal tubule and collecting duct. Owing to the nature of the defect, hyperchloremic non-anion gap metabolic acidosis and high urine pH despite severe systemic acidosis is characterized.
Typical manifestations of distal RTA are growth retardation, rickets, polyuria and nephrocalcinosis.
We experienced a case of... |
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- A Case of Scleredema
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Bin Cho, Ik Jun Lee
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Clin Exp Pediatr. 1993;36(12):1770-1773. Published online December 15, 1993
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Scleredema is a rare skin disease of unknown cause involving the face, neck upper portion of the trunk, and proximal upper extremities.
The clinical features of it are nonpitting, solid emema or stiffness of the neck, which may be sudden or insidious onset. Preceeding upper respiratory infection or diabetes mellitus have been frequently discribed to be associated with disease. A monoclonal... |
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